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This marker is associated in several studies with an increased risk of coronary insufficiency, ischemic stroke, and peripheral arterial occlusive disease [65-67]

So on the narrow question does it stop working after N weeks, the honest answer is: no published evidence says it does, and the mechanism actually argues against it

Animal studies show a more pronounced impact, where AOD9604 increased lipolysis and prevented fat accumulation, but these results dont fully translate to humans (example)

Benefits and challenges of video consulting for mental health diagnosis and follow-up: A qualitative study in community care

AOD-9604 stimulates lipolysis and inhibits fat cell formation, CB4211 enhances insulin sensitivity and fatty acid metabolism, and Tesamorelin targets visceral fat through growth hormone-mediated pathways