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Although there is a broad agreement that naturally occurring food folate is not as bioavailable as folic acid, uncertainties still exist in relation to the extent of these differences, particularly in the context of a whole diet

Moreover, although valuable information is obtained through research conducted on animals and in vitro, extrapolation of these findings to human populations continues to be challenging because many studies fail to provide longterm data on the safety and efficacy of extracts of papaya and carrot (Miao et al

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