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Furthermore, when cultured in hypoxic conditions (5% O 2 ), BM-MSCs have shown an incremented expression of genes involved in chondrogenic differentiation (ACAN, KRT19, BARX1), immunomodulation (CXCL5, SFN), and cell survival and proliferation (GPX3, TXNIP) compared to BM-MSCs cultured under atmospheric O 2