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found that iron-loaded microglia did not exhibit typical pro-inflammatory or anti-inflammatory activation at the transcriptomic level

However, it is becoming increasingly evident that autophagosomes can selectively engulf substrates including aggregate-prone proteins (aggrephagy) 61 , dysfunctional mitochondria (mitophagy) 62 and the endoplasmic reticulum (ER-phagy) 63

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(61) reported that vitamin D supplementation lowers the expression of TLR2, TLR4, and TLR9 in monocytes during autoimmune disease

In zinc-deficient states, fecal and urinal zinc losses are rapidly decreasing [31,39,40]