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This may contribute to a predisposition to NTHi infections in CF and COPD patients who demonstrate compromised lower airway AMP activity despite mounting an inflammatory response (Persson et al., 2017

The failure of antioxidant systems, particularly glutathione peroxidase 4 (GPX4), which reduces lipid hydroperoxides to non-toxic lipid alcohols, leads to the collapse of membrane integrity and ferroptotic cell death ( A central regulator of ferroptosis and oxidative stress responses is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that controls the expression of a wide array of antioxidant and cytoprotective genes