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That said, there isnt really a downside to doubling the dose of this supplement to achieve that greater HMB dose and see an uptick in creatine consumption, other than the increased expense.7 You also get 5mg of BioPerine per dose, a branded black pepper fruit extract thats been shown to increase nutrient absorption in numerous studies looking at various ingredients.21 Its unclear how much it would influence that HMB dose, though its highly doubtful that it would double the efficacy

High-dose benzodiazepine use and QTc interval prolongation, a latent class analysis study