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However, gaps remain in the understanding of subset functions and regulatory mechanisms: in vitro studies rely on limited cell lines (e.g., HD11 macrophages, DF-1 fibroblasts), and the lack of long-term primary immune cell culture systems hinders simulation of in vivo cellular functions in complex microenvironments

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Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms

MiRNAs mainly induce the degradation of mRNAs or inhibit their translation by interacting with the 3-UTR of target mRNAs, leading to changes in regulatory factors in cellular physiological processes