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Sci Rep (2021) 11:5493

Konopleva M, Mikhail A, Estrov Z, Zhao S, Harris D, Sanchez-Williams G, Kornblau SM , Jung J, Kliche KO, Jiang S, Przepiorka D, Snodgrass HR, Estey EH, Andreeff M

Mechanistic aspects of carotenoid biosynthesis

Nutrients 5:24752482

In contrast to the potential resolution seen in AKI, the chronic inflammatory state in CKD fuels a detrimental cycle involving sustained immune cell activity, continuous release of pro-inflammatory and pro-fibrotic mediators, and progressive pathological tissue remodeling