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PLB has been shown to exert its anti-inflammatory and antioxidant effects by inhibiting signaling pathways such as PI3K/Akt/mTOR and nuclear factor-kappaB [34, 35]

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Berberine should be avoided by those who are pregnant or breastfeeding, as it may worsen jaundice in infants or result in kernicterus, a condition in which prolonged high bilirubin levels can cause irreversible effects (28)