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All use therefore remains explicitly within the research domain, and the tolerability profile is not fully characterized

doi: 10.1001/archneurol.2010.227 116 DreherSIGrubbaPvon ToerneCMoruzziAMaurerJGojTet al

Thus, long cycles became more prevalent after the first dose, from ~6% to 11%, but decreased in prevalence for the next cycle, at 7.3%

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Specifically, C-arm fluoroscopy-guided subchondral BMAC injection not only significantly reduced pain and enhanced knee scores (as shown in figures/tables) but also was associated with a significant early reduction in MRI-detected bone marrow lesion severity at 3 months, suggesting an early radiological response to treatment