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[251] found that puerarin (2, 4, and 8 M) may improve LPS-induced inflammation injury in gastric epithelial cells GES-1, and decrease expression of NLR family pyrin domain containing 3 (NLRP3), ASC, cleaved caspase-1, IL-1 and IL-18 by activating AMPK/SIRT1 signaling pathway and inhibiting NLRP3 inflammasoma-mediated apoptosis

This energy deficit leaves the cell vulnerable to further oxidative damage, creating a vicious cycle of depletion and dysfunction that is incredibly difficult to break without targeted nutritional support

246 Similarly, trials in inflammatory diseases failed to meet efficacy endpoints, suggesting limited benefit in complex human conditions

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