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In cell culture studies, concentrations of 10 to 1,000 nanomolar (nM) are used, with the physiological range at approximately 200 nM

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This suggests two possibilities: The conversion of NR/NAM to Niacin might be slower or incomplete in the body NR and NMN might have additional ways to influence NAD+ levels beyond just converting to Niacin Despite being largely converted to NAM or NA, enough NR can reach tissues to promote biological effects. (25) Additionally, the full picture of how NMN is utilized in the body remains unclear

Furthermore, Imai et al