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[4] Clinical practice typically involves reviewing medication history, assessing liver function, performing a full blood count, and considering haematological or hepatological referral when levels are markedly elevated without clear cause

Additionally, patients may experience secondary systemic symptoms such as confusion, tendon reflex hyperactivity, reversible dementia, mood swings, psychotic symptoms, and hypertension,

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It is increased in acute inflammatory disorders and causes major changes in total plasma concentration of these drugs even though drug elimination is unchanged

The power of the placebo effect should not be underestimated