Excessive ROS can damage cellular DNA, proteins, and lipids, resulting in cellular dysfunction ( Figure 1
and Nicolet, J
As the first treatment strategy, conventional synthetic (cs) DMARDs like methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, chloroquine, and gold salts should be used as soon as RA is diagnosed
PLCs are classically coupled to GPCRs, therefore we tested orphan GPCR Olfr39 overexpressing cells identified in the same screen [32] and observed the prototypical pattern of Ms4a15 OE in viability, Ca 2+ , and lipid regulation (Supplementary Fig

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