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Van Laer et al., 2013)

On the other hand, an increase in oxidative stress markers, including those associated with DNA damage, was observed in exposed animals, along with the induction of NF-kB dependent pro-inflammatory mediators: TNF-, IL-1, IL-6 and COX-2

These pressures compound (no pun intended) the demand-supply imbalance and make the shortage timeline less predictable