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Repeated diving behavior and terrestrial apnea bouts likely contribute to a preconditioning effect, which protects seal cells against oxidative damage, though genomic data also support a role for evolutionary pressure in shaping GSH metabolism in both pinnipeds and cetaceans [24,25,26, 64]

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There is also evidence that peripheral inflammation driven by gut dysbiosis can reduce expression of key protein degradation systems in the brain (such as ubiquitinproteasome pathway and autophagy genes), thereby accelerating the accumulation of toxic proteins [101]

HDL cholesterol should be above 50 in females and 40 in males