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Therefore, we may recommend this therapy to patients undergoing rigorous physical activities, those recovering from injuries, and individuals who may have compromised immune systems or gut health issues

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However, iron chelation can only be considered as a therapeutic strategy after the confirmation of its efficacy and safety in randomized controlled trials

We found that reduced UA and agricultural work, proxy for increased exposure to pesticides, were both associated with PD in the same cohort 13 , although the study was not designed to identify interaction effects

Logically, local administration of antioxidant agents into the target site may be comparably superior, especially considering the increase in bioavailability and accurate targeting of the joint, bypassing the pharmacokinetic challenges and reducing exposure to inappropriate sites