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3.2 Clonal evolution and Darwinian selection under therapeutic pressure Beyond the selection of rare pre-existing resistant clones, therapeutic intervention itself functions as a powerful evolutionary force that reshapes tumor architecture through Darwinian selection

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Bassig BA, Willhauck-Fleckenstein M, Shu XO, Koh WP, Gao YT, Purdue MP, et al

Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies

2.2 Oxidative stress Oxidative stress induced by metabolic stress is closely associated with several pathological conditions, including mastitis, during the periparturient period in dairy cattle (26, 51, 52)