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Furthermore, persistent activation of the TCR and the type I IFN- signalling triggered mitochondrial changes via increasing NAD + consumption due to both CD38 overexpression and PARP activation in CD8 + T cells, resulting in lower spare respiratory capacity, decreased bioenergetic fitness and thus increased tendency to die

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Key virulence factors include internalin-mediated host cell adhesion and invasion, flagella-driven motility, the positive regulatory factor A (PrfA)-regulated transcriptional control of major virulence genes, the listeriolysin O-induced disruption of phagosomal membranes, the phospholipase-mediated evasion of host defense mechanisms, actin polymerization-dependent intracellular and intercellular spread, sigma factor-driven stress responses, biofilm formation and the development of resistance to antimicrobial agents

doi: 10.2174/0125899775373406250411104442, PMID: [DOI] [PubMed] [Google Scholar] Surez Castro E., Santos-Garca D., de Deus Fonticoba T., Expsito Ruz I., Tuas Gesto C., Macas Arrib M

Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion