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congestive cardiomyopathy, pulmonary edema, prolongation of the QT interval Chronic exposure: Hematologic : Microcytic hyprochromic anemia is also common with all heavy metal intoxications & may develop after 1-2 weeks after acute ingestion

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RAGE overexpression upregulates the expression of Fas (CD95) and its ligand FasL and promotes the formation of a death-inducing signaling complex (DISC), which recruits and activates caspase-8, directly cleaves caspase-3, or amplifies the apoptotic signal of the mitochondrial pathway via the Bid protein (tBid) 85,141

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