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Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload

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10.3748/wjg.v20.i12.3255 62

Unfortunately, this conventional clinical strategy sheds little light on the underlying infertility etiology or the functional integrity of a patients spermatozoa and has thus proven to be of limited utility in predicting fertilization success ( via the coupling of ultra-high magnification with machine learning [i.e., motile sperm organelle morphology examination (MSOME)], with the goal of standardizing the detection of morphological anomalies, it remains uncertain which elements of sperm structure define the functionality of this highly specialized cell