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These microbiome changes reversed rapidly, however, when the obese mice were returned to a normal, lean diet 79

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The S-targeting mAbs included both neutralizing and non-neutralizing molecules which displayed high, yet differential, activity in multiple antibody effector assays dependent on the antigenic target, suggesting a role for the Fv in facilitating both neutralization and Fc effector functions as all isolated mAbs were cloned into the same rh-IgG1 backbone

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