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A prior study displayed that mitochondria-derived vesicles (MDVs) were indispensable in OB differentiation and that Opa1 knockdown or Fis1 overexpression in OBs enhanced mitochondrial fragmentation and favoured MDV formation, increasing mitochondrial secretion and accelerating OB generation (163)

While mice and rats are convenient laboratory animal models, the fact that they are nocturnal animals that normally experience completely different UV exposure levels to humans means that the role of UV light exposure in cataract development in rodents must be carefully interpreted with respect to cataract formation in the human lens