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BKhadkaD.PanditA.et al (2014)

Later, the [Ca2+cyt] elevation activates the calcium sensor activated via phosphorylation by mitogen-activated protein kinase kinases (MAPKKs)

So its been studied in inflammatory bowel diseases like Crohns disease and ulcerative colitis, ankylosing spondylitis, multiple sclerosis, lupus, psoriasis, lichen planus, type 1 diabetes, and Hashimotos [disease], fibrositis