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Mild side effects, like slight soreness at the injection site, may occur but usually resolve quickly

doi: 10.1038/s41556-025-01774-y

However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research

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Neutralization of SARS-CoV-2 spike-protein pseudovirus with soluble ACE2, NAbs, and COVID-19 plasma We next investigated whether spike protein pseudoviruses could be neutralized by soluble ACE2 (sACE) or spike protein-specific NAbs (Fig