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Andreu-Vieyra, C

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Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, Guzik TJ, Harrison DG

Moreover, while the use of ASNS alone can cause adverse effects such as pancreatitis and thrombosis, its combination with CB-839 effectively mitigates these risks ( 4.3.5 Combination of ammonium metabolism drugs and radiotherapy Excessive ROS production leads to an imbalance between ROS and the cells antioxidant defense, resulting in DNA damage, a key mechanism in radiation therapy-mediated tumor treatment ( Chemical inhibition of key points of glutamine metabolism, such as GLS and MYC, or genetic knockdown of these genes and glutamine transporters, suppresses glutamine decomposition, thereby inhibiting crucial CSC-driving pathways (WNT/-catenin, the oxidative stress response, and the DNA damage response), resulting in CSC depletion both in vitro and in vivo and enhancing tumor radiosensitivity

Mobile phase B was 90% acetonitrile with 10 mM ammonium acetate, 0.1% ammonium hydroxide and 0.1% medronic acid