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Lanzino M, Garofalo C, Morelli C, Le Pera M, Casaburi I, McPhaul MJ, et al

doi: 10.1007/s13238-021-00846-7 15 MarcucciFRumioC

Pharmacol Biochem Behav 99:371380 Watkins LR, Hutchinson MR, Rice KC, Maier SF (2009) The toll of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia

Abbreviations 5-FU : 5-Fluorouracil CIM : Chemotherapeutics-induced intestinal mucositis ROS : Reactive oxygen species IL : Interleukins NF-B : Nuclear factor-kappa B SLC7A11 : Solute carrier family 7 member 11 SLC3A2 : Solute carrier family 3 member 2 GSH : Reduced glutathione GPx4 : Glutathione peroxidase 4 Nrf2 : Nuclear factor erythroid-related factor 2 CAT : Catalase SOD : Superoxide dismutase MDA : Malondialdehyde FAO : Food and Agriculture Organization WHO : World Health Organization DMSO : Dimethyl sulfoxide i.p

This is consistent with the idea that pH changes caused by GAPDH inhibition are not due to a general inhibition of glycolysis but specific to a block at the level of GAPDH and in part due to accumulation of upstream glycolytic intermediates