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The external cream (often containing a mild antifungal and a soothing ingredient) can be applied to the vulva to alleviate itching of the outside skin, while the internal cream or suppository treats the yeast inside the vagina

Sometimes a person can benefit from a single-area treatment, but rarely

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This property can be useful in certain medical conditions, such as septic shock, where high levels of nitric oxide contribute to blood vessel dilation and decreased blood pressure