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Cell Signaling Technologies, 3662, RRID:AB_2219400), ACO1 (1:1000, GeneTex, GTX128976, RRID:AB_2885857), ACO2 (1:1000

IDO1 depletes L-tryptophan storage and induces the production of immunoregulatory molecules interferon- (IFN-), tumor-necrosis factor (TNF) and IL-1 ( The decline of protein metabolism that is related to the diminishing concentration of certain amino acids, leads to the endoplasmic reticulum (ER) stress

Hunziker EB, Quinn TM, Hauselmann HJ

HerbikA.GiritchA.HorstmannC.BeckerR.BalzerH

Therefore, early phenotype prediction is warranted, but this is complicated as most lcFAODs lack a clear genotype-phenotype correlation