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The remaining patients present with neurologic (~30%) or psychiatric (10%) symptoms in their third or fourth decade.2 Pathogenesis In normal human copper metabolism, the dietary intake and absorption of copper is in excess of physiologic needs

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GPX1 prevents cytotoxic peroxide-induced oxidative damage, lipid peroxidation and protein degradation

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Therefore, employing a combination of Gln transporter inhibitors may be a more effective approach for tumor suppression