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Existing evidence points toward melatonins role as an antioxidant showing systemic therapeutic benefits in PD-relevant clinical trials (dyskinesia, sleep disorder) 187 , which combined with amphiphilic nature allowing for BBB diffusion further encourages therapeutic focus revisiting melatonin as a mitophagy agonist with NF-B and Nrf2 activating effect mentioned prior 187

The coordinates and geometric restraints for each inhibitor were created from smiles using Grade 49 with the qm+mogul option

These injections are safer and less likely to cause tissue damage, making them a reliable choice for extended treatment plans

This bidirectional effect highlights the necessity for context-specific modulation of the autophagy-ferroptosis axis

Therefore, mGSH arises from the cytosol GSH by the activity of specific carriers ( Figure 1