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4.9 Ferroptosis in Huntingtons disease HD is an autosomal dominant neurodegenerative disorder caused by CAG repeat expansions in the HTT gene, which encodes mutant huntingtin (mHTT) proteins containing elongated polyglutamine (polyQ) tracts

However, the mechanism underlying its activation is still poorly understood

Zhang S, Zhang Y, Feng Y, Wu J, Hu Y, Lin L, et al

While adjuvants are included in vaccines to enhance immune responses, they can also contribute to ASIA