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The first vaccine an individual receives induces a strong primary immune response that shapes responses to subsequent infection and vaccination, an effect known as imprinting, said senior author Michael S

Zhang X, Piano I, Messina A, DAntongiovanni V, Cr F, Provenzano G, et al

Gastroenterology (2017) 153(2):4209

To this end, the development of new therapies, ideally targeting synovitis and inflammatory-related bone erosion in joints, as well as regulating those inflammation-independent factors that can also interfere with bone homeostasis in RA, such as the general RANKL signaling pathway, would be promising for remodeling bone homeostasis in RA

This common question depends on you, as everyone's body and specific goals are different