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It is a methylquinolinium derivative that targets the NNMT enzyme

Obesity trials didnt move into Phase III because efficacy signals werent strong enough at the doses tested, but the safety data generated is still useful for characterising the peptides tolerability profile in preclinical research planning

At one month, realistic outcomes look like small but measurable shifts: a few pounds down if youve kept a sustained deficit, a slight waist reduction, steadier training, and improved daily activity

(Biochem Pharmacol 2018) documented a reduction of -35% in white adipose tissue, -40% in adipocyte volume, -5.1% in body weight and -30% in plasma cholesterol in just 11 days in obese mice (DIO), without any change in food intake

We announced the assignment to APC 5313 in the October 2021 OPPS quarterly update CR (Transmittal 10997, Change Request 12436, dated September 16, 2021)