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123 In-vitro drug release assessments using a dialysis membrane indicated that the rapid drug release observed with AMS-NE (100% at 4 h) could be attributed to the small nanoscale surface area of the nanoemulsion, resulting in easy permeation through the dialysis membranes

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[1] [2] The clinical trials that supported FDA approval did not identify muscle cramps or leg cramps as occurring at a significantly higher rate in semaglutide-treated patients compared to placebo groups

doi:10.1016/j.jdermsci.2015.09.003 8