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Notably, unlike the conserved Site 1, Site 2 lacks evolutionary conservation

Based on this, Nichols [10] postulated that MDMA represents a novel class of compound, in that it possesses unique effects, which means that it cannot be classified as either a hallucinogen or a psychostimulant

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Lin-Hu Quan, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers