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Support overall cellular health

Nat Med (2018) 24:90822

Therefore, it is suggested that alternative inhibitors targeting other domains should be developed [112]

In contrast, in a randomized, controlled trial (RCT) of 43 young children with various types of primary mitochondrial diseases (mean age at entry: 5.6 years), oral DCA administered at a dose of 12.5 mg/kg every 12 h for 6 months was well tolerated and caused no adverse changes in peripheral nerve electrical conduction, compared with placebo [29] , although some asymptomatic decline in nerve conduction was found with longer drug exposure [30]

1, 2, 3, 4 This has motivated research into lifestyle interventions and drugs for prevention and treatment of these diseases