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For example, catalpol attenuates depression-like behaviour in pathological hyperglycaemic states, and its antidepressant mechanism is attributed to the upregulation of PI3K/AKT/Nrf2/HO-1 signalling pathway by reversing the abnormal phosphorylation of PI3K and Akt, as well as the abnormal levels of Nrf2 protein, HO-1 and superoxide dismutase, glutathione peroxidase, glutathione transferase, and reducing glutathione (Zhao et al., 2012)

Nature 569 , 503508

Obviously, the potential of targeting zinc transporters in cancer therapy has been identified, and the development of targeted small molecule drugs for clinical cancer patients is imminent

Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes

Surprisingly, glutaredoxin was present in a more reduced form in the trr1 mutant