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This reduces the inflammatory burden on the central nervous system without requiring a compound to cross the blood-brain barrier itself

Macrophage migration inhibitory factor (MIF) is essential for inflammatory and neuropathic pain and enhances pain in response to stress

The results of experimental studies indicate that low IGF-1 concentrations could play a role in the course of ALS disease by accelerating neurodegenerative changes and worsening clinical symptoms 9

A systemic evaluation of the effect of dsRNA contamination on mRNA vaccine expression and immunogenicity

Loss of tibial motor neurons after nerve autografting and tubulation nerve repair may attribute to delayed and incomplete axonal regeneration due to axotomy with disrupted endoneuria 10,27