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Phenothiazines also have peripheral and/or central antagonistic activity against alpha-adrenergic, serotonergic, histaminic (H1-receptors), and muscarinic receptors

An open-label, single-arm and phase IIa clinical study has been designed for investigating the efficacy of combining focused ultrasound-driven BBB disruption with bevacizumab in the treatment of glioblastoma patients

However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo

As well, mutation in the LRRK2 gene has been associated with familial PD

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