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Description

Unfortunately, no measurements of free iron in these FTH-silenced CSCs were performed, but it is plausible that increased levels of free iron would be expected

This method comprises contacting a cell with a ferroptosis modulator, which comprises a compound having the structure of formula (IV): R 1 is selected from the group consisting of aryl, C 1-6 alkyl-aryl, and C 3-10 carbocycle, wherein the aryl, C 1-6 alkyl-aryl, and C 3-10 carbocycle may be optionally substituted with an atom or a group selected from the group consisting of halo, deuterium, C 1-6 alkyl, CF 3 , and combinations thereof