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This immediately flags a common cause: Dietary Factors: Vegans and strict vegetarians are at a higher risk of deficiency if they dont consume fortified foods or supplements

Although F1 and F2 peptides comprise only a small part of GST, they show significant inhibition efficiencies in the GST-catalyzed reaction

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The action of synthetic DMARDs is intracellular (Kiely and Nikiphorou 2018)