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Purkinje neurons coexist with specialized astrocytes (Bergman glia), which protect the neurons.Subjects with ASD have activated microglia [35], which export copious amounts of glutamate [42].Glutamate is a mitochondrial toxin [43-45], and is selectively toxic to neurons [46-48].Could glutamate be the cause of the mitochondrial dysfunction and selective Purkinje neuron degeneration observed in autism

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Prebiotics enhance probiotic proliferation and restore gut microbiota balance, which may alleviate gastrointestinal symptoms in ASD patients (Palmer et al., 2025)

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