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It results from the effect of reactive oxygen species on the guanosine base in DNA and is typically detected in urine

The European respiratory journal

The immune system is broadly divided into two major components: innate immunity and adaptive immunity

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[,] The lung diseases, for example, interstitial lung disease, pleural fibrosis, COPD, and even obstructive sleep apnea (OSA, which is characterized by chronic intermittent hypoxia [CIH] [] ), may contribute to the development of respiratory failure-related HH