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Future investigations based on the MAD theory should take care when taking approaches to target only single microbes such as HSV-1 or else using a broad-spectrum antibiotic without an anti-biofilm measure, as such strategies would likely be only partially productive

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b Primary failure (n=23), Secondary loss of response (n=10), Intolerance (n=4), other (n=4)

[61,] [62 ]These results were criticized on a number of grounds, including the noticeable difference between the vitamin C and placebo, lack of intravenous administration, and termination of treatment with tumor progression