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However, there is paradox about the effect of AMPK on AD

Further, this complex binds with hypoxia-responsive elements (HREs) and activates the gene expression for the NOX genes ( NOX1, NOX 2, NOX 4 , and NOX 5 ) NOX enzymes also contribute to the production of free radicals Superoxide and hydrogen peroxide (50) by transferring the electrons from NADPH to oxygen (51)