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By focusing on solvent exposure regions, structural optimization of compound molecules can enhance drug affinity and selectivity, improve drug solubility and bioavailability, reduce drug side effects, and overcome drug resistance

Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons

All outcomes were measured for both eyes except 1 eye that had another disease process that could affect visual function, but only 1 eye was selected for obtaining aqueous samples

Mitochondrial dysfunction is recognized as one of the primary hallmarks of biological aging, and MOTS-c directly addresses this mechanism

The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome