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This support the nephroprotective role of Spirulina reported by previous studies [72,73,74]

Endothelial dysfunction and prothrombotic reprogramming Endothelial cells (ECs) exposed to NET components undergo profound functional reprogramming, shifting from physiological vascular homeostasis toward inflammationdriven endothelial injury and a procoagulant phenotype [78]

But it also explains why transition periods can look like worsening

10.1161/JAHA.117.006387 J

The following conditions for the ion transfer were used: 4500 V capillary voltage, 500 V endplate offset, 4 L/min dry gas at 200 C, 1.8 bar nebulizer pressure and 10 eV collision energy