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The comparatively higher sample size addresses biological variability, possible attrition and death rates (e.g., Doxorubicin toxicity), and type I error inflation in pairwise comparisons (Tukeys post-hoc test)

Between January 2011 and December 2020, California reported 24 to 49 cases per 100,000 individuals aged 15 or older, according to the Drug Enforcement Administrations Diversion Control Division in NFLIS-Drug Special Report: Gabapentin and Pregabalin Reported in NFLIS, 20112020. Migraines Sometimes prescribed as a preventive treatment, Gabapentin diminishes the frequency and severity of migraines by stabilizing nerve activity and dampening pain pathways in the brain