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doi: 10.3389/fgene.2022.1009883 Received 02 August 2022 Accepted 15 September 2022 Published 29 September 2022 Volume 13 - 2022 Edited by Ertugrul Filiz, Duzce University, Turkey Reviewed by Farman Ali, Fujian Agriculture and Forestry University, China Ajit Ghosh, Shahjalal University of Science and Technology, Bangladesh Updates Copyright 2022 Duan, Yu, Wang, Fu, Cao, Yang and Ye

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This means that hydroxycobalamin stays in the body for longer periods of time and can provide sustained levels of vitamin B12, which may be beneficial for individuals with severe or chronic vitamin B12 deficiency

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However, there is ample evidence to suggest that the environmental factors and gene-environment interactions may be important causes of neurodegenerative diseases